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Folate, Vitamin B12, and Vitamin B6 are necessary for a number of biochemical functions involved in methylation. Folate has a key role in methylation and in reducing levels of homocysteine (a marker of poor methylation) and inflammation. Folate is also required for cell division due to its role in DNA and RNA synthesis, having important implications for fertility, development, and the reduction of birth defects. Vitamin B12 is vital for methylation, gene expression, and cell differentiation regarding fertility. Vitamin B6 is also important for methylation, among other factors such as the nervous system and metabolic health. Overall, supporting methylation is also essential for the healthy detoxification and metabolism of estrogen in the liver.
CoQ10 is a potent antioxidant that helps to support the regeneration of cells and has been found to be beneficial in supporting fertility by improving egg quality.